I use Microsoft Word for all of my stories--as do many people. But one thing that upset me every time I opened up a new file, I would have to go through all of the settings and fix them.
I had to change the font to Time Roman 12.
I had to change the line spacing from single to double-space.
It also started out in italics, and had to remove that.
Also, since I've published in the Amazon Kindle store and Smashwords (not currently on the latter), I had to format the identations so instead of using the tab key to create paragraphs, they would be automatically created once I hit return after the end of each paragraph.
Now, there is probably a way to make sure all new documents start out the way I want it. I haven't figured it out, if there is. In the meantime, I have a story template saved, which I use to start every new story.
You may want to consider using one, if you find yourself always changing new documents to format to your settings.